The dissemination and the reach of scientific knowledge have increased at a blistering pace. In this context, e-print servers have played a central role by providing scientists with a rapid and open mechanism for disseminating research without having to wait for the (lengthy) peer-review process. While helping the scientific community in several ways, e-print servers also provide scientific communicators and the general public with access to a wealth of knowledge without having to pay hefty subscription fees. Arguably, e-print servers' value has never been so evident, for better or worse, as during the COVID-19 pandemic. This motivates us to study how e-print servers are positioned within the greater Web, and how they are "used" on Web communities. Using data from Reddit (2005-2021) and 4chan's Politically Incorrect board (2016--2021), we uncover a surprisingly diverse set of communities discussing e-print papers. We find that real-world events and distinct factors influence the e-prints people are talking about. For instance, there was a sudden increase in the discussion of e-prints, corresponding to a surge in COVID-19 related research, in the first phase of the pandemic. We find a substantial difference in the conversation around e-prints and their actual content; in fact, e-prints are often being exploited to further conspiracy theories and/or extremist ideology. Overall, our work further highlights the need to quickly and effectively validate non peer-reviewed e-prints that get substantial press/social media coverage, as well as mitigate wrongful interpretations of scientific outputs.